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Human Immunodeficiency Virus 1 (HIV-1) PhenoSense Integrase-994

Test info

Test name:

Human Immunodeficiency Virus 1 (HIV-1) PhenoSense Integrase

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

INSTI
Integrase strand inhibitor
Monogram Integrase Inhibitor Resistance
PhenoSense integrase
Raltegravir

Useful for:

The PhenoSense Integrase® assay is a phenotypic resistance test used to determine the susceptibility of a patient's HIV to integrase inhibitors. Integrase inhibitors block HIV replication by preventing the virus from integrating into the host cell's DNA. Raltegravir (Isentress®) is the first approved drug in this class of HIV antiretroviral drugs.

Specimen

Specimen type:

EDTA plasma

Collection container:

Lavender (EDTA), 4mL x2

Volume:

3.0 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

Processing instructions:

Spin
Transfer serum to aTransfer vial/tube for small volume specimens (Sarstedt), labelled as EDTA plasma
Freeze immediately

Do not send specimens until they are completely frozen, as nucleic acid degradation occurs rapidly at ambient and higher temperatures.

Specimen integrity is compromised with freeze/thaw cycles.

Transport container:

Transfer vial/tube for small volume specimens (Sarstedt) x 2 or 3

Required forms/information:

Current viral load (≥ 500 copies/mL)

Transport and stability:

Frozen (strict)

Performance

Performing lab:

Monogram Biosciences (S3200) via LabCorp (550230): R-NX

Days set up:

Varies

TAT:

23 days

Method:

Polymerase chain reaction (PCR) amplification and viral culture

Clinical and Interpretive info

Reference ranges:

See report

Billing

CPT codes:

87903

Tracking

Date created:

06/05/2013

Revised date:

04/14/2022

Review date:

04/12/2022