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Encainide and metabolites, serum or plasma-2837

Test info

Test name:

Encainide and metabolites, serum or plasma

Test number:

2837

Excellian order number:

LAB2837

Abbreviation:

Encainide

Alternate names:

Enkaid

Tests included:

Encainide
o-Demethylencainide (ODE)
3-Methoxy-o-demethylencainide (MODE)

Useful for:

Therapeutic drug management

Specimen

Specimen type:

Serum

Collection container:

Red serum vial/tube, 5 mL

Volume:

1.0 mL

Minimum volume:

0.2 mL

Collection instructions:

Trough levels are most reproducible

Processing instructions:

Allow sample to clot
Spin within two (2) hours of sample collection
Transfer serum to a Serum/plasma transfer vial/tube (MedTox), labelled as serum

Transport container:

Serum/plasma transfer vial/tube (MedTox)

Alternate specimen type:

Lithium heparin (Li hep) plasma
Sodium heparin (Na hep) plasma

Alternate collection container:

Dk green heparin (Li or Na), no gel

Alternate collection instructions:

Immediately following collection, mix sample by inverting 8 - 10 times to prevent clotting

Alternate processing instructions:

Spin within two (2) hours of sample collection
Transfer plasma to a Serum/plasma transfer vial/tube (MedTox), labelled as the appropriate plasma type

Transport and stability:

Refrigerated (preferred)

Ambient - <3 days

Frozen - OK

Reason for rejection:

Gel-barrier tubes are not recommended

Performance

Performing lab:

MedTox Laboratories (176): R-MX

Days set up:

Varies

TAT:

4 days

Method:

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Clinical and Interpretive info

Reference ranges:

Encainide: 15 - 100 ng/mL

ODE: 100 - 300 ng/mL

MODE: 60 - 300 ng/mL

Clinical information:

10% of patients do not form therapeutic concentrations of the active metabolites, ODE and MODE. In these patients the recommended range for the encainide concentration is 300 - 1200 ng/mL

Billing

CPT codes:

G0480

Subject to medical necessity (Y/N):

Yes

LCD/NCD:

Medical necessity

Hospital EAP/charge code:

17002425

Clinic EAP/charge code:

30G04801C

Tracking

Date created:

11/15/2021

Revised date:

01/03/2024

Review date:

01/03/2024