• All IHC stains will include a positive control tissue

• IgA labels plasma cells and related lymphoid cells containing IgA
• IgA stains will show an interstitial dendritic pattern within lymphoid follicles, (this represents extracellular immune complexes which are bound to the surface of specialized follicular dendritic cells)
• IgA will label occasional B cell lymphomas

Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• This antibody reacts with heavy chains (alpha) of human IgA (Fc-part)
• This antibody labels plasma cells and various lymphocytes

Staining pattern

• Cytoplasmic (plasma cells) and cell surface membrane (lymphocytes)

References

1. Taylor CR et al: The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. J Clin Pathol 1974; 27:14-20.
2. Taylor CR et al: The immunohistological detection of intracellular immunoglobulin in formalin-paraffin sections from multiple myeloma and related conditions using the immunoperoxidase technique. Clin exp Immunol 1974; 8:417-29.