All IHC stains will include a positive control tissue

• CD31 is a very sensitive and specific marker for endothelial differentiation, and is probably the first choice for vascular markers in studying benign and malignant vascular tumors
• CD31 reacts weakly with mantle zone B cells, peripheral T cells, and neutrophils
• In cryostat sections and blood smears, CD31 also labels megakaryocytes, platelets, and some plasma cells

Submit a formalin-fixed, paraffin-embedded tissue

Formalin-fixed, paraffin-embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• Reacts with a glycoprotein found in endothelial cells and platelets

Staining pattern

• Cytoplasmic and cell membrane-based staining

References

1. De Young and Wick, et. al.: CD31: An Immunospecific Marker for Endothelial Differentiation in Human Neoplasms; Appl. Immunohistochem. 1:97-100, 1993.
2. Longacre et. al.: CD31: A New Marker for Vascular Neoplasia; Advances in Anat. Pathol. 1:16-20, 1994.