The 4Kscore Test calculates your risk for aggressive prostate cancer by measuring several proteins in the blood and combining that with clinical findings.

It can be used after an abnormal PSA result if you are considering a prostate biopsy.

***For order by Allina Health providers only***

4Kscore Test is not indicated for men if:

• Previous diagnosis of prostate cancer
• Younger than 45 years of age
• Within 96 hours after a digital rectal examination
• Receiving 5-alpha reductase inhibitors (5ARIs) therapy within the previous 6 months
• Undergone any significant, invasive urological procedure or therapy that may be associated with secondary PSA elevation within the prior 6 months

Speckled top Serum separator tube (SST) X 2 (collection tubes provided in kit).

Kit/specialty tubes must be requested from the Central lab supply prior to patient arriving in the lab

• Patient should arrive with completed 4Kscore test requisition.
• Time sensitive: Specimens should be collected Monday – Thursday. Specimens must be received at the Central lab by 1pm.
• Immediately following collection, mix sample thoroughly by gentle inversion, 5 times

• Allina Health facilities should order Cancer Genetic Send Out (LAB12636).

1. Allow sample to clot.
2. Centrifuge for 10 minutes.

Kit

4Kscore test requisition- to be completed by the provider 

Refrigerated - 72 hours

**SPECIMEN MUST BE SHIPPED WITHIN 24HRS OF COLLECTION**

Electrochemiluminescence Immunoassay

Interpretive report will be send directly to the provider

The 4Kscore test result is the probability of finding high-grade, aggressive prostate cancer (Gleason 7 or higher) if a prostate biopsy were to be performed.

A 4Kscore <5.0 is associated with decreased likelihood of a Gleason score ≥7 on biopsy. Prostate biopsy is required for the diagnosis of cancer. The test is not recommended more than once every 6 months.