High in sarcoidosis, more often when the disease is active. Of value in assessing the response of sarcoidosis to corticosteroid therapy.

Stop administration of Captopril, Enalapril, or Lisinopril for 12 hours prior to sample collection (reduces ACE activity).

Gold serum separator (SST) tube

Immediatley following collection, mix sample by inverting 5 times

1. Allow specimen to clot for a minimum of 30 minutes
2. Spin within two (2) hours of sample collection

Gold serum separator (SST) tube

Red serum vial/tube, 5 mL

1. Allow specimen to clot
2. Spin within two (2) hours of sample collection
3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) labelled as "serum"

Transfer vial/tube with cap - 12mL (LabCorp)

Ambient  (preferred) - 10 days

Refrigerated  - 10 days

Frozen - 7 months

Freeze/thaw cycles - stable x4

• Captopril, enalapril, or lisinopril administration
• Hemolyzed specimen
• Icteric specimen
• Whole blood
• Cerebrospinal fluid (CSF)
• EDTA plasma specimen received

Kinetic

0 - 2 years:   18 - 95 units/L
3 - 14 years: 22 - 108 units/L
≥ 15 years:   14 - 82 units/L

Changes in serum ACE correlate with clinical status and results of gallium scans (which reflect presence and activity of inflammatory granulomatous lesions). Falling ACE level is a favorable prognostic sign. Rising levels may reflect activity uncontrolled by therapy.