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Neuromyelitis Optica (NMO)/Aquaporin-4-IgG fluorescence-activated cell sorting (FACS) assay, spinal fluid-12780

Test info

Test name:

Neuromyelitis Optica (NMO)/Aquaporin-4-IgG fluorescence-activated cell sorting (FACS) assay, spinal fluid

Test number:

12780

Excellian order number:

LAB12780

Abbreviation:

NMOFC

Alternate names:

AQP
AQP4
Aquaporin
Devic's Antibody
NMO (Neuromyelitis Optica)
NMO-IgG
NMO/AQ
Optic Neuritis Ab
Transverse Myelitis Antibody
Vision Loss Antibody

Tests included:

Test will reflex to a titer, if indicated, at an additional charge

Useful for:

Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
Diagnosis of autoimmune AQP4 channelopathy
Distinguishing NMOSD from multiple sclerosis early in the course of disease

Specimen

Specimen type:

Cerebrospinal fluid (CSF)

Collection container:

Sterile vial

Volume:

3.0 mL

Minimum volume:

2.0 mL

Transport container:

Sterile vial

Transport and stability:

Refrigerated (preferred) - 28 days

Frozen - 28 days

Ambient - 72 hours

Specimen retention time:

28 days

Performance

Performing lab:

Mayo Clinic Laboratories (NMOFC): R-MM

Days set up:

Mo, Tu, Th

TAT:

3 - 6 days

Method:

Flow Cytometry

Clinical and Interpretive info

Reference ranges:

Negative

Cautions:

A negative result does not exclude a diagnosis of neuromyelitis optica spectrum disorder (NMOSD). Recommend serum be tested if CSF tests negative and neuromyelitis optica spectrum disorder is suspected. AQP4-IgG antibodies may drop below detectable levels

Billing

CPT codes:

86053
86053 - NMO/AQP4-IgG FACS titer (if appropriate)

Hospital EAP/charge code:

17027437
17028488 - Titer (if indicated)

Clinic EAP/charge code:

308605303
308605300 - Titer (if indicated)

Tracking

Date created:

08/19/2015

Revised date:

12/27/2023

Review date:

12/27/2023