Microsatellite Instability, Tumor-Pathology add-on

Test info

  
Microsatellite Instability, Tumor
  
Pathology add-on
  
MSI
  
DNA Mismatch Repair-related HNPCC
Hereditary Nonpolyposis Colon Cancer (HNPCC)
Lynch syndrome
Lynch
Microsatellite Instability
MSI
Tumor microsatellite Instability
MMR
Mismatch repair
Mismatch repair deficiency
  

Evaluation of tumor tissue to identify patients at high risk for having Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer.

Evaluation of tumor tissue for clinical decision-making purposes given the prognostic and therapeutic implications associated with microsatellite instability phenotypes

Specimen

  
Tissue Block
  
Preferred amount of tumor area with sufficient percent tumor nuclei: tissue 72 mm(2)
  
Minimum amount of tumor area: 18 mm(2) (at least 40% tumor nuclei for endometrial specimens and at least 20% tumor nuclei for colorectal specimens)
  

Submit a formalin-fixed, paraffin-embedded tissue block with acceptable amount of tumor tissue.

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  
Tissue Slide
  

1 stained and 5 unstained slides

  

Submit 1 slide stained with hematoxylin and eosin and 5 unstained, nonbaked slides with 5-micron thick sections of the tumor tissue.

  

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Genetics: Inherited Cancer Syndromes Patient Information

  • Complete and submit the form 
  • All information requested is required in order for your request to be completed
  

Ambient

  
  • Decalcified specimens
  • Low tumor percentage
  • Insufficient amount of tumor
  • Nonformalin-fixed
  • Fresh tissue
  • Cytology smears

Performance

  
Mayo Clinic Laboratories (TMSI): R-NX
  
Mo -Fr
  
2 - 5 days
  

Polymerase Chain Reaction (PCR)

Clinical and Interpretive info

Billing

  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
81301
88381 - Microdissection, manual
  
Yes
  

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Medicare billing request

Tracking

  
05/08/2023
  
05/23/2024
  
07/11/2023