Cytomegalovirus (CMV) genotype-994
Test info
CMV Drug Resistance Genotyping
Foscarnet Resistance Genotyping
Ganciclovir Resistance Genotyping
UL54
UL97
Treatment of CMV diseases includes three licensed drugs: ganciclovir, foscarnet and cidofovir. All three drugs inhibit the viral DNA polymerase through various mechanisms. Over time, as CMV makes copies of itself, the virus can change its structure. These changes may make CMV resistant to the effects of antiviral drugs. Therefore, it is important to detect resistance as quickly and accurately as possible for proper management of CMV infection.
Specimen
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting
- Spin
- Transfer plasma to a Screw-cap polypropylene frozen transport vial/tube - 4mL (LabCorp), labelled as EDTA plasma, within two (2) hours of sample collection
- Freeze
Avoid repeated freezing and thawing of specimen.
Bronchial lavage/wash
Sterile vial/container
Sterile vial/container
Plasma/CSF:
Frozen
BAL:
Refrigerated
Performance
DNA Sequencing Polymerase Chain Reaction (PCR)
Clinical and Interpretive info
An interpretive report will be provided