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Pediatric Autoimmune Encephalopathy/CNS Disorder Evaluation, Serum-994

Test info

Test name:

Pediatric Autoimmune Encephalopathy/CNS Disorder Evaluation, Serum

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Encephalitis
Myelitis
Encephalopathy
Myelopathy, pediatric
Myelopathy, child

Tests included:

PCSI Peds Autoimmune CNS Interp, S
Anti-Neuronal Nuclear Ab, Type 1
CASPR2-IgG CBA, S
DPPX Ab IFA, S
GABA-B-R Ab CBA, S
GAD65 Ab Assay, S
GFAP IFA, S
LGI1-IgG CBA, S
mGluR1 Ab IFA, S
MOG FACS, S
Neurochondrin IFA, S
NMDA-R Ab CBA, S
NMO/AQP4 FACS, S
Purkinje Cell Cytoplasmic Ab Type Tr

For reflex tests, see algorithm on Clinical and Interpretive info tab

Useful for:

Evaluating children with autoimmune central nervous system disorders using serum specimens

Specimen

Patient preparation information:

For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference.

Specimen type:

Serum

Collection container:

Red serum vial/tube, 10 mL

Volume:

4 mL

Minimum volume:

2 mL

Collection instructions:

Immediately following collection, thoroughly mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Centrifuge within two (2) hours of sample collection
Transfer serum to a Screw cap transfer vial/tube (Mayo T914), labelled as serum

Transport container:

Screw cap transfer vial/tube (Mayo T914)

Alternate collection container:

Gold serum separator (SST) tube

Alternate collection instructions:

Immediately following collection, thoroughly mix sample by gently inverting 5 times

Alternate processing instructions:

Allow sample to clot for a minimum of 30 minutes
Centrifuge within two (2) hours of sample collection
Transfer serum to a Screw cap transfer vial/tube (Mayo T914), labelled as serum

Alternate transport container:

Screw cap transfer vial/tube (Mayo T914)

Transport and stability:

Refrigerated (preferred) – 28 days

Ambient – 72 hours

Frozen – 28 days

Specimen retention time:

28 days

Performance

Performing lab:

Mayo Clinic Laboratories (PCDES): R-NX

Days set up:

Varies

TAT:

8 - 12 days

Method:

Immunofluorescence assay (IFA)

Cell-binding assay (CBA)

Fluorescence activated cell sorting assay (FACS)

Radioimmunoassay (RIA)

Immunoblot (IB)

Clinical and Interpretive info

Reference ranges:

See report

Clinical information:

Pediatric Autoimmune Encephalopathy/
Central Nervous System Disorders Evaluation Algorithm-Serum

Billing

CPT codes:

86341
86363
86053
86255 x 10

Additional CPT codes (if appropriate):
84182 AN1BS
86256 AN1TS
84182 AN2BS
86255 DPPCS
86256 DPPTS
86256 GABIS
86255 GFACS
86256 GFATS
86255 GL1CS
86256 GL1TS
86363 MOGTS
86255 NCDCS
86256 NCDTS
86256 NMDIS
86053 NMOTS
84182 PCTBS
86256 PCTTS

Tracking

Date created:

03/17/2023

Revised date:

03/20/2023

Review date:

03/20/2023