• All IHC stains will include a positive control tissue

• SSTR2a is a highly sensitive and specific marker for meningiomas. However, rare meningiomas may show no staining for this marker, and these tumors might be further studied with progesterone receptor and EMA
• This marker can be used to differentiate spindle cell neoplasms of the central nervous system, in conjunction with S100 (positive in Schwannoma), SOX10 (positive in schwannoma), STAT6 (positive in hemangiopericytoma/solitary fibrous tumor; HPC/SFT), progesterone receptors (positive in meningiomas and some carcinomas), and CD34 (variably positive in HPC/SFT)
• Positive staining is also seen in pancreatic islets, gastric endocrine cells, and vessels

Submit a formalin-fixed, paraffin embedded tissue block

Formalin-fixed, paraffin embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• SSTR2a is encoded by the SSTR2 gene and is a transmembrane protein present in cerebrum and kidney.
• This marker is highly expressed by meningiomas

Staining pattern

• Strong diffuse membranous and cytoplasmic staining

References

1. Menke JR, Raleigh DR, Gown AM, Thomas S, Perry A, Tihan T. Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen. Acta Neuropathol. 2015:21.