• In paraffin tissue, the antibody labels mast cells and is most useful in identifying mast cell related diseases

Submit a formalin-fixed, paraffin embedded tissue

Formalin-fixed, paraffin embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications:

• The antibody reacts with human mast cell tryptase, isolated from human lung tissues
• Tryptase is a protease found in the granules of mast cells, and is a mediator of inflammation
• Anti-mast cell tryptase labels mast cells in many tissues including respiratory and GI tracts, skin, conjunctiva and brain
• This antibody does not label basophils

Staining pattern:

• Cytoplasmic granular staining

References

1. Walls et al: Immunohistochemical identification of mast cells in formaldehyde-fixed tissue using monoclonal antibodies specific for tryptase. J Pathol 1990;162:199-126.