TP53 deletion is a recurring abnormality in AML, CLL, MDS, and plasma cell dyscrasia disorders including Plasma Cell Myeloma.

TP53 deletion is a poor cytogenetic risk factor across several disorders including AML, CLL, MDS and myeloma.

This test can be ordered individually or as part of a Plasma Cell Dyscrasia FISH Panel (See the individual panel test for more details).

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

Transfer aspirate from syringe to transport container. 

Submit entire specimen unspun.

Sterile vial/tube

or

Dk green Sodium heparin (Na hep), no gel

Bone marrow core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or

Whole blood:

Dk green Sodium heparin (Na hep), no gel

Whole Blood:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

Submit entire specimen

Bone marrow core: 

Sterile vial/tube or cup

Whole Blood:

Dk green Sodium heparin (Na hep), no gel

AHL Cytogenetics oncology request

Ambient

• Improper label (unlabeled or mislabeled)
• Wrong container (anticoagulant or solution)
• Delay in transport
• Improper storage
• Leaking container
• Slides broken beyond repair

Fluorescence in situ hybridization (FISH)

Normal or Abnormal with interpretation

Medical necessity