• All IHC stains will include a positive control tissue

• Useful in identifying cells of renal epithelial origin
• RCC is detectable in 93% of primary and 84% of metastatic renal cell carcinomas
• RCC also may react with breast lobular and ductal epithelium, epididymal tubular epithelium and colloid of thyroid follicles

Submit formalin-fixed, paraffin embedded (FFPE) tissue block

Formalin-fixed, paraffin embedded (FFPE) tissue block

FFPE tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications:

• Human proximal nephrogenic renal antigen (carbohydrate domain of a glycoprotein)
• RCC binds to a glycoprotein expressed in renal proximal tubule epithelial cells

Staining pattern

• Membrane and coarse globular cytoplasmic staining

References

1. Avery AK et al: Use of antibodies to RCC and CD 10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 24(2); 204-210, 2000.
2. Yoshida SO et al: Monoclonal antibody to a proximal nephrogenic renal antigen: immuno9histochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas. Cancer Research, 49; 1802-1809, 1989.
3. Oosterwijk E, et al: Immunohistochemical analysis of monoclonal antibodies to renal antigens: application in the diagnosis of renal cell carcinoma, AJP, 123,2:301-309, 1986.
4. Vessella RL et al: Monoclonal antibodies to human renal cell carcinoma: recognition of shared and restricted tissue antigens. Cancer Research, 45: 6131-6139, 1985.