Antiglomerular basement membrane antibodies-13364
Test info
Antiglomerular BM Ab
Glomerulonephritis
Goodpasture pulmo-renal syndrome
Goodpasture syndrome
Anti-GBM antibodies (glomerular basal membrane; Goodpasture antigen) are important for the diagnosis of glomerulonephritis, which may be accompanied by pulmonary hemorrhage (Goodpasture pulmo-renal syndrome). Due to clinical symptoms similar with systemic vasculitis, it is appropriate to concurrently carry out tests for anti-GBM and Antineutrophil cytoplasmic antibodies (ANCA).
Specimen
Immediatley following collection, mix sample by gently inverting 5 times
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
Gold serum separator (SST) tube
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
- Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x3
- Microbially contaminated, heat-treated specimens or specimens containing visible particulate
- Grossly hemolyzed specimen
- Grossly lipemic specimen
Performance
Multiplex flow immunoassay
Clinical and Interpretive info
0.0 - 0.9 units
This test is often used in conjunction with the antineutrophil cytoplasmic antibody (ANCA) test for Wegener granulomatosis and vasculitis.