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Propeptide Type 1 Collagen-13400

Test info

Test name:

Propeptide Type 1 Collagen

Test number:

13400

Excellian order number:

LAB13400

Abbreviation:

PINP

Alternate names:

Intact N-terminal propeptide of type 1 procollagen
P1NP

Useful for:

This test is used for measurement of Intact N-Terminal Propeptide of Type 1 Procollagen (PINP) levels in serum.

Limitations:

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Specimen

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube

Volume:

0.5 mL

Minimum volume:

0.4 mL
(Note: This volume does not allow for repeat testing.)

Collection instructions:

Immediately following collection, mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within 45 minutes of sample collection

Transport container:

Gold serum separator (SST) tube

Alternate collection container:

Red serum vial/tube, 5 mL

Alternate processing instructions:

Allow sample to clot
Spin within 45 minutes of collection
Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum

Alternate transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Transport and stability:

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycle: Stable x 3

Reason for rejection:

Non-serum sample received

Performance

Performing lab:

LabCorp Burlington (140850): R-LC

Days set up:

Tu, Th

TAT:

3-5 days

Method:

Immunochemiluminometric assay (ICMA)

Clinical and Interpretive info

Reference ranges:

Premenopausal females: 13.9-89.1 ng/mL

Postmenopausal females: 10.4-97.8 ng/mL

Males ≤ 45 years of age: 21.8-96.0 ng/mL

Males >45 years of age: 18.3-86.1 ng/mL

Cautions:

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. When evaluating subsequent samples, collect the samples at the same time of the day, as there is a diurnal variation of P1NP with the values being higher at night. The measurement of P1NP has limited specificity as it is reflective of the rate of bone turnover in general. Type I collagen is synthesized by fibroblasts and therefore can be found in loose connective tissues together with other collagen types. However, since bone is the major collagenous organ and also metabolically active throughout life, the majority of the circulating P1NP is of osteoblast origin. PINP is metabolized in the liver. Severe liver disease may affect clearance from the circulation and give rise to elevated serum P1NP levels. As with most assays utilizing secondary antibodies, samples containing antibodies (such as heterophilic antibodies) that react with rabbit/goat IgG may cause erroneous results.

Billing

CPT codes:

82523

Subject to medical necessity (Y/N):

Yes

LCD/NCD:

Medical necessity

LOINC code:

Result 47255-5

Tracking

Date created:

04/09/2019

Revised date:

08/22/2023

Review date:

08/22/2023