• All IHC stains will include a positive control tissue

• Useful in identifying alpha-beta T-cell receptors from T-cell clones or polyclonal populations of T-cells
• Aids in diagnosing T-cell lineage neoplasms

Submit a formalin-fixed, paraffin embedded tissue block

Formalin-fixed, paraffin embedded (FFPE) tissue block

Tissue section mounted on a charged, unstained slide

Ambient (preferred)

• Unlabeled/mislabeled block
• Insufficient tissue
• Slides broken beyond repair

Immunohistochemical staining and microscopic examination

If requested, an interpretive report will be provided

Specifications

• Recognizes T-cell receptor (TCR) beta subunit, that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules
• TCR is composed of a heterodimer; 95% of T cells this consists of an alpha and beta chain and 5% of T cells this consists of gamma and delta chains

 Staining pattern

• Cytoplasmic

References

1. Ohshima K et al: Virchows Arch. 1999 Aug;435(2):92-100.