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Alpha defensin, lateral flow assay, synovial fluid-994

Test info

Test name:

Alpha defensin, lateral flow assay, synovial fluid

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

ALDEF
Alpha defensin
Alpha-defensin
PJI
Prosthetic joint infection
Synovasure

Useful for:

Detection of alpha defensins 1-3, human host response proteins, in synovial fluid of adults with a total joint replacement who are being evaluated for revision surgery.

Limitations:

This test is not intended to be used to determine timing for reimplantation in 2-stage procedures
This test should only be used for patients with a total joint prosthesis

Specimen

Specimen type:

Synovial fluid

Collection container:

Red serum vial/tube, 5 mL

Volume:

0.6 mL

Minimum volume:

0.1 mL

Processing instructions:

Transfer fluid from the syringe used for collection to a Red serum vial/tube, 5 mL

Transport container:

Red serum vial/tube, 5 mL

Alternate collection container:

Screw cap transfer vial/tube (Mayo T914)

Alternate transport container:

Screw cap transfer vial/tube (Mayo T914)

Required forms/information:

Specimen source
Type of joint

Transport and stability:

Refrigerated (strict) – 7 days

Ambient - No

Frozen - No

Specimen retention time:

7 days

Reason for rejection:

Gross hemolysis
If fluid is not obtained from a prosthetic joint, testing will be canceled

Performance

Performing lab:

Mayo Clinic Laboratories (ALDEF): R-NX

Days set up:

Mo - Fr, Su

TAT:

2 days

Method:

Lateral Flow Assay (LFA)

Clinical and Interpretive info

Reference ranges:

Negative; No alpha defensin detected in synovial fluid, suggesting absence of prosthetic joint infection.

Billing

CPT codes:

83518

Tracking

Date created:

10/16/2020

Revised date:

08/28/2025

Review date:

08/28/2025