Substance P is a neuropepetide present in the central and peripheral nervous system. Substance P is a neurotransmitter released in response to pain and other noxious stimuli. Substance P is a neuropeptide of the tachykinin class that also includes neurokinin. Substance P is found in the brain, spinal cord, and peripheral tissues and is released from nerve endings in response to stimuli. Increased substance P levels can occur in neurogenic inflammation and physiological stress and may be associated with carcinoid or neuroendocrine tumors.

Patient should be fasting 10-12 hours prior to collection.

Antacid medication or medication that may affect intestinal motility should be discontinued if possible for at least 48 hours prior to collection.

Gold serum separator (SST) tube

Immediatley following collection, mix sample by gently inverting 5 times

1. Allow sample to clot for a minimum of 30 minutes at room temperature
2. Centrifuge at 3400 for 10 minutes
3. Transfer serum into a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum, as soon as possible
4. Freeze at -20 °C immediately

Transfer vial/tube with cap - 12mL (LabCorp)

Frozen (strict) - 4 weeks

Refrigerated - NO

Ambient - NO

Specimens received refrigerated or room temperature

Enzyme Immunoassay (EIA)

<1700 pg/mL