HLA B*58:01, Allopurinol hypersensitivity-994

Test info

  
HLA B*58:01, Allopurinol hypersensitivity
  
994
  
LAB994
  
MSO
  
Allopurinol Hypersensitivity
B58
B5801
HLA B*58:01
HLA B58
  

Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T-cell receptors to elicit an immune response. The presence of the HLA B*58:01 allele increases the susceptibility to allopurinol SCAR in several populations studied.

Specimen

  
EDTA whole blood
  
  
7 mL
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

  

Lavender (EDTA), 10mL

  

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

  

Ambient (preferred)

Refrigerated (OK)

  
  • Hemolysis
  • Clotted specimen
  • Insufficient volume of DNA

Performance

  
LabCorp Burlington (167351): R-NX
  
Varies
  
6 - 7 days
  

Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.

Clinical and Interpretive info

  

An interpretive report will be provided

Billing

  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
81381
  
Yes
  
Result 13299-3
  

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Molecular Medicare billing request

Tracking

  
05/29/2019
  
05/23/2024
  
04/05/2022