Trisomy 12/ 13q14 by FISH-4280G (bone marrow) or 4280H (blood)

Test info

  
Trisomy 12/ 13q14 by FISH
  
4280G (bone marrow) or 4280H (blood)
  
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
  
Del13/CEP12
  
CLL
CLL Full Panel
CLL Prognostic Panel
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
Trisomy 12
+12
FISH
Fluorescence In Situ Hybridization
  

Trisomy 12 is a recurring abnormality of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL). According to current NCCN CLL guidelines, trisomy 12 is classified as an intermediate cytogenetic risk factor. 

This test can be ordered individually or as part of a CLL Full Panel or CLL Prognostic Panel (See the individual panel tests for more details).

Specimen

  
Bone marrow aspirate: 5mL (minimum 3 mL)
  

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

  1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
  2. Immediatley following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

 

  
5 mL
  
3 mL
  

Transfer aspirate from syringe to transport container.

  

Submit entire specimen unspun.

  

Sterile vial/tube 

  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow core
Heparinized whole blood
Touch prep slides
  

Core: 

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  
10 mm for core, 5 mL for whole blood
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

  

Submit entire specimen unspun

  

Bone marrow core:

Sterile vial/tube

Whole Blood:

Dk green Sodium heparin (Na hep), no gel

  

AHL Cytogenetics oncology request

  

Ambient

  
Specimens retained until completion of all testing
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Delay in transport
  • Improper storage
  • Leaking container
  • Slides broken beyond repair

Performance

  
AHL - Cytogenetics: X
  
Mo-Fr
  
7 business days
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation.

 

Billing

  
88271 x 3
88275
88291
  
Yes
  

Tracking

  
03/18/2021
  
08/29/2022
  
09/08/2022