Acetylcholine Receptor (AChR) Binding Ab-994

Test info

  
Acetylcholine Receptor (AChR) Binding Ab
  
994
  
LAB994
  
MSO
  
AChR binding antibodies
ACRAB
Myasthenia gravis antibody
ACh receptor
  

In vitro diagnostic semiquantitative determination of autoantibodies against the acetylcholine receptor in human serum and plasma. This assay is the primary test for confirming the diagnosis of acquired Myasthenia gravis.

  

In rare cases AChR antibodies can be found in patients with other autoimmune disorders or with thymoma without MG.1

The causative autoantibody cannot be identified in up to 10 percent of patients with MG.

Specimen

  

No isotopes administered 24 hours prior to venipuncture.

  
Serum
  
  
1.0 mL
  
0.3 mL
(Note: This volume does not allow for repeat testing.)
  

Immediatley following collection, mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within 45 minutes of collection
  

Gold serum separator (SST) tube

  
  
  1. Allow sample to clot
  2. Spin within 45 minutes of collection
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) labelled as serum
  
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cylces - 3

  
  • Gross hemolysis
  • Gross icterus
  • Gross lipemia

Performance

  
LabCorp Burlington (085902): R-NX
  
Mo - Fr
  
2 - 4 days
  

This assay measures antibodies that precipitate solubilized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (αBTX).
Antibodies that bind to the receptor regions that are not sterically blocked by the αBTX are detected.

Clinical and Interpretive info

  

Negative:   0.00 - 0.24 nmol/L

Billing

  
86041
  
Result 11034-6

Tracking

  
11/30/2001
  
01/04/2024
  
08/17/2023