In vitro diagnostic semiquantitative determination of autoantibodies against the acetylcholine receptor in human serum and plasma. This assay is the primary test for confirming the diagnosis of acquired Myasthenia gravis.
No isotopes administered 24 hours prior to venipuncture.
Gold serum separator (SST) tube
Spin and transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) within 45 minutes of collection.
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cylces - 3
This assay measures antibodies that precipitate solubilized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (αBTX).
Antibodies that bind to the receptor regions that are not sterically blocked by the αBTX are detected.
Negative: 0.00 - 0.24 nmol/L