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TP53 mutation-994

Test info

Test name:

TP53 mutation

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

P53
CLL
BCLL
TP53 gene somatic mutation analysis

Useful for:

Evaluating chronic lymphocytic leukemia patients at diagnosis or during disease course for the presence of TP53 gene variants indicating high risk of disease progression and adverse outcomes.

This test is not intended for the evaluation of patients suspected of having an inherited or germline TP53 cancer syndrome (eg, Li Fraumeni syndrome)

Specimen

Specimen type:

EDTA whole blood

Collection container:

Volume:

3 mL

Minimum volume:

1 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

Processing instructions:

Send whole blood specimen in original tube. Do not aliquot.

Required forms/information:

Molecular Hematopathology Patient Information

Transport and stability:

Refrigerated (preferred) - 10 days

Ambient - 10 days

Specimen retention time:

2 weeks

Reason for rejection:

Gross hemolysis
Extracted DNA
Moderately to severely clotted

Performance

Performing lab:

Mayo Clinic Laboratories (P53CA): R-NX

Days set up:

Mo - Fr

TAT:

8 -14 days

Method:

Polymerase Chain Reaction (PCR) and Sanger Sequencing

Clinical and Interpretive info

Billing

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81352

Tracking

Date created:

03/13/2023

Revised date:

07/10/2023

Review date:

03/14/2023