UGT1A1 Irinotecan toxicity-994

Test info

UGT1A1 Irinotecan toxicity

Irinotecan (Camptosar®) is used, or under evaluation, in a broad spectrum of solid tumors, and is often prescribed for treating patients with metastatic cancer of the colon or rectum, especially when 5-fluorouracil treatment has not been entirely successful. Severe toxicity (eg, grade 4 neutropenia) is commonly observed in cancer patients receiving irinotecan who carry the UGT1A1*28 allele, also called TA. This test result will provide valuable information to physicians prior to initiating or modifying treatment or supplementing treatment with additional drugs. UGT1A1 variants have also been reported in patients with disorders of bilirubin metabolism, such as Crigler-Najjar Types I and II, as well as Gilbert syndrome. Between 80% to 100% of Caucasian patients with Gilbert syndrome are reported to have either one or two copies of UGT1A1*28. G71R (*6), a UGT1A1 variant reported in Asian patients with Gilbert syndrome, is not detected by this assay.


EDTA whole blood
5.0 mL
3.0 mL

Immediately after collection, mix sample thoroughly by gentle inversion, 8 - 10 times, to prevent clotting


Lavender (EDTA), 10mL


ACD whole blood

Yellow ACD (A or B)




Yellow ACD (A or B)


Ambient (preferred) - 7 days

Refrigerated - 1 month

Frozen - 2 years

  • Hemolysis
  • Quantity not sufficient for analysis
  • Improper container/anticoagulant


LabCorp RTP (511200): R-NX
Weekly/as needed
6 - 9 days

Polymerase chain reaction (PCR) and capillary electrophoresis

Clinical and Interpretive info


An interpretive report will be provided


This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
Result 41044-9

Medical necessity

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed

Molecular Medicare billing request