CD68 by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test info

CD68 by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • KP1 reacts with cells of monocyte/macrophage or myelomonocytic lineage (this includes epithelial histiocytes, multinucleated histiocytes, osteoclasts, giant cells in giant cell tumors of bone, Gaucher's cells, sea blue histiocytes)
  • KP1 will also react with neutrophils, mast cells and basophils; and will stain myeloid leukemias (useful in the workup of a chloroma)
  • KP1 can stain a wide variety of non-Hodgkin's lymphomas of B-cell phenotype (most frequently KP1 positive NHL's are small lymphocytic and diffuse, small cleaved NHL)
  • KP1 stains granular cell tumors, and Schwann cells in benign peripheral nerve sheath tumors
  • KP1 is not highly specific; KP1 also may react with hepatocytes, kidney tubules and glomeruli, pancreatic acini and islets, skin epithelium, sweat glands, connective tissue, and endothelial cells
  • KP1 reactivity has also been reported in MFH, renal cell carcinoma, malignant melanoma, meningioma, glioblastoma, infiltrating duct carcinoma of the breast



Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair


AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination

Clinical and Interpretive info


If requested, an interpretive report will be provided



  • CD68/KP1 is an antibody that recognizes an intracellular glycoprotein associated with lysosomes, phagosomes, and primary granules of neutrophils. It is a very useful marker for identifying macrophages/histiocytes

Staining pattern

  • Granular cytoplasmic based staining


  1. Weiss, et. al.: CD68; A Review; Appl. Immunohistochemistry 2(1):2-8, 1994.
  2. Horny, et. al.: Assessment of the Value of Immunohistochemistry in the Subtyping of Acute Leukemia on Routinely Processed Bone Marrow Biopsy.


88342 - 1st stain
88341 - each additional stain