Epilepsy, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid-12691

Test info

  
Epilepsy, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid
  
12691
  
LAB12691
  
EPC2
  
Dipeptidyl aminopeptidase-like protein 6
EPIEC
Metabotropic glutamate receptor 1
Seizures
Spells
Leucine-Rich Glioma Inactivated Protein-1 IgG
  
  • Epilepsy, Interpretation, CSF
  • AMPA-R Ab CBA, CSF
  • Amphiphysin Ab, CSF
  • Anti-Glial Nuclear Ab, Type 1
  • Anti-Neuronal Nuclear Ab, Type 1
  • Anti-Neuronal Nuclear Ab, Type 2
  • Anti-Neuronal Nuclear Ab, Type 3
  • CASPR2-IgG CBA, CSF
  • CRMP-5-IgG, CSF
  • DPPX Ab IFA, CSF
  • GAD65 Ab Assay, CSF
  • GABA-B-R Ab CBA, CSF
  • GFAP IFA, CSF
  • LGI1-IgG CBA, CSF
  • mGluR1 Ab IFA, CSF
  • Neurochondrin IFA, CSF
  • NMDA-R Ab CBA, CSF
  • Purkinje Cell Cytoplasmc Ab Type Tr
  • Purkinje Cell Cytoplasmic Ab Type 2
For reflex tests, see algorithm on Clinical and Interpretive info tab
  

 

  • Investigating new onset cryptogenic epilepsy with incomplete seizure control and duration of less than 2 years using spinal fluid specimens
  • Investigating new onset cryptogenic epilepsy plus 1 or more of the following accompaniments:
    • Psychiatric accompaniments (psychosis, hallucinations)
    • Movement disorder (myoclonus, tremor, dyskinesias)
    • Headache
    • Cognitive impairment/encephalopathy
    • Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, premature graying of hair, myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus, idiopathic adrenocortical insufficiency) or "multiple sclerosis"
    • History of cancer
    • Smoking history (20+ pack years) or other cancer risk factors
    • Investigating seizures occurring within the context of a subacute multifocal neurological disorder without obvious cause, especially in a patient with past or family history of cancer

Specimen

  
Cerebrospinal fluid (CSF)
  

Sterile vial/container

  
4.0 mL
  
2.0 mL
  

Refrigerated (preferred) - 28 days

Frozen - 28 days

Ambient - 72 hrs

  
28 days
  
  • Gross hemolysis
  • Gross lipemia
  • Gross icterus

Performance

  
Mayo Clinic Laboratories (EPC2): R-NX
  
Varies
  
8 - 12 days
  

Immunofluorescence Assay (IFA), Cell Binding Assay (CBA) and Western Blot (WB), Radioimmunoassay (RIA), and Immunoblot (IB)

Clinical and Interpretive info

  

See report

  
Negative results do not exclude autoimmune epilepsy or cancer.

Billing

  
86255 x 17
86341

Additional CPT codes (if appropriate):
84182-AGNBC
86256 AGNTC
86256-AMPIC
84182-AMIBC
84182-AN1BC
86256 AN1TC
84182-AN2BC
86256 AN2TC
86256 AN3TC
86256 APHTC
86256 CRMTC
84182-CRMWC
86255-DPPCC
86255-DPPCC
86256-GABIC
86255-GFACC
86256-GFATC
86255-GL1CC
86256-GL1TC
86255 NCDCC
86256 NCDTC
86256-NMDIC
86256 PC2TC
84182-PCTBC
86256 PCTTC

Tracking

  
11/18/2014
  
02/01/2024
  
02/20/2023