ATM/TP53 by FISH-4280H (blood) or 4280G (bone marrow)

Test info

  
ATM/TP53 by FISH
  
4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
ATM/TP53
  
CLL
CLL Full Panel
CLL Prognostic Panel
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
TP53
TP53 Deletion
11q-
11q22
17p13.1
  

Deletion of 11q22 (ATM) and 17p13.1 (TP53) are recurring abnormalities of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL).

This test can be ordered individually or as part of a CLL Full Panel or CLL Prognostic Panel (see the individual panel tests for more details).

Specimen

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2.0 mL
  

Only one specimen tube is required to perform all ordered cytogenetics testing.

The more testing ordered, the closer to the optimal volume requirements is preferred.

  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whole blood:

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

EDTA whole blood:

Lavender (EDTA), 4mL

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

  
  • AHL Cytogenetics oncology request
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container

Performance

  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation.

A deletion of either 11q22 (ATM) or 17p13.1 (TP53) is classified as an unfavorable cytogenetics prognostic indicator in CLL/SLL according to NCCN.

Billing

  
88271 x 2
88275
  
Yes

Tracking

  
03/18/2021
  
04/06/2021