Antiscleroderma-70 antibodies-13355

Test info

  
Antiscleroderma-70 antibodies
  
13355
  
LAB13355
  
SCL
  
Anti-Scl 70
ANTISCL70M
  

Semiquantitative result of IgG class

  

Differential diagnosis of scleroderma (progressive systemic sclerosis)

Specimen

  
Serum
  
  
1.0 mL
  
0.5 mL
Submission of the minimum volume does not allow for repeat testing
  

Immediatley following collection, mix sample by gently inverting 5 times

  
  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within two (2) hours of sample collection
  

Gold serum separator (SST) tube

  
  
  1. Allow sample to clot
  2. Spin
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum, within two (2) hours of sample collection
  
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

  

Hemolysis, icterus, lipemia, gross bacterial contamination

Performance

  
LabCorp Burlington (018705): R-LC
  
Mo - Sa
  
1 - 3 days
  

Multiplex flow immunoassay

Clinical and Interpretive info

  

0.0 - 0.9 AI

  

Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.

Billing

  
86235
  
Result 27416-7

Tracking

  
03/27/2019
  
11/15/2019
  
02/16/2021