Rearrangement of MYC is a common abnormality in Acute B-Cell Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL) and an indication of a histologic (Richter’s) transformation.
This test can be ordered individually or as part of a CLL full panel (see the individual panel test for more details).
Dk green Sodium heparin (Na hep), no gel - 4mL
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
Dk green Sodium heparin (Na hep), no gel
Lavender (EDTA), 4mL
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.
Although not listed in the NCCN cytogenetics prognostic table, a MYC rearrangement may activate transcription and be an indication of a histologic (Richter’s) transformation to a more aggressive lymphoma.