MYC by FISH [peripheral blood or bone marrow]]-4280H (blood) or 4280G (bone marrow)

Test info

  
MYC by FISH [peripheral blood or bone marrow]]
  
4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
6Q21/MYC
  
CLL
CLL Full Panel
Chronic Lymphocytic Leukemia
MYC
SLL
Small Lymphocytic lymphoma
8q24
8q24 rearrangement
  

Rearrangement of MYC is a common abnormality in Acute B-Cell Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL) and an indication of a histologic (Richter’s) transformation.

This test can be ordered individually or as part of a CLL full panel (see the individual panel test for more details).

Specimen

  
Sodium heparin (Na hep) whole blood
  
5 mL
  
2 mL
  
  • Only one specimen tube is required to perform all ordered cytogenetics testing.
    • The more testing ordered, the closer to the optimal volume requirements is preferred.
  • Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting
  

Dk green Sodium heparin (Na hep), no gel - 4mL

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whole blood (not recommended):

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

Whole blood:

Lavender (EDTA), 4mL

  
  • AHL Cytogenetics oncology requisition
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container

Performance

  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation.

Although not listed in the NCCN cytogenetics prognostic table, a MYC rearrangement may activate transcription and be an indication of a histologic (Richter’s) transformation to a more aggressive lymphoma.

Billing

  
88271 x 2
88275
  
Yes

Tracking

  
03/18/2021
  
04/06/2021