Androgen receptor image by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test info

  
Androgen receptor image by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
AR
  
  • All IHC stains will include a positive control tissue
  
  • Androgen receptor (AR) positivity may be used to identify patients with metastatic breast cancer who may benefit from Bicalutamide therapy (prostate cancer drug)
  • The majority of estrogen receptor positive breast cancers will also be AR positive; androgen receptors are most frequently seen in luminal A and B invasive breast cancers
  • ARs are also seen in approximately one-third of basal-like cancers
  • AR positive, estrogen receptor negative tumors are frequently apocrine type; these may be triple negative or HER2 positive tumors
  • Request AR IHC evaluation on breast cases using image analysis
  • AR is also useful in the diagnosis of salivary duct carcinomas. Approximately 90% of these tumors will be AR positive, and P63 negative

Specimen

  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

Tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled
  • Insufficient tissue
  • Slides broken beyond repair

Performance

  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

Clinical and Interpretive info

  

If requested, an interpretive report will be provided

  

Specifications

  • This antibody is used to identify the androgen receptor in tumor cells

Staining patterns

  • Strong nuclear staining

References

  1. Niemeier LA, Dabbs DJ et al: Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol (2010) 23, 205–212.
  2. Collins LC et al: Androgen Receptor Expression in Breast Cancer in Relation to Molecular Phenotype: Results from the Nurses’ Health Study. Mod Pathol. 2011 July; 24(7): 924–931. doi:10.1038/modpathol.2011.54
  3. Robinson JLL et al: Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. The EMBO Journal (2011) 30, 3019–3027.

Billing

  
88342 - 1st stain
88341 - each additional stain
88361 - CAS Morphometric

Tracking

  
05/01/2017
  
02/25/2019
  
10/02/2020