Carbamazepine sensitivity HLA associations-994

Test info

  
Carbamazepine sensitivity HLA associations
  
994
  
LAB994
  
MSO
  
Carbamazepine sensitivity
HLA A*3101
HLA A*31:01
HLA A3101
HLA B*1502
HLA B*15:02HLA B1502
Oxcarbazepine Sensitivity
  

To avoid possible adverse reactions, this test has been recommended for patients who may be prescribed Carbamazepine and oxcarbazepine. Two HLA alleles are associated with adverse reactions to these drugs. The alleles are HLA B*15:02, which is more common in individuals of Asian descent, and HLA A*31:01, which is more common in individuals of European descent. This test evaluates the presence or absence of these alleles.

Specimen

  
EDTA whole blood
  
  
7.0 mL
  
3.0 mL
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

  

Lavender (EDTA), 4mL

  

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form along with the sample.

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed
  

Ambient (preferrred) 

Refrigerated (OK)

  

Insufficient volume of DNA

Performance

  
LabCorp Burlington (167443): R-NX
  
Mo - Fr
  
2 - 6 days
  

Next Generation Sequencing (NGS), sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP) and/or sequence-specific primers (SSP) as needed to obtain the required resolution

Clinical and Interpretive info

  

Negative

A negative test result does not rule out an adverse reaction with the drug Carbamazepine and oxcarbazepine

Billing

  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
81381 x 2
  

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed

Molecular Medicare billing request

Tracking

  
05/31/2019
  
04/12/2022
  
04/05/2022