To identify patients with MYC (chromosome 8q24) rearrangements including Burkitt lymphomas and to help differentiate diffuse large b-cell lymphoma from high grade lymphoma.

This test can be ordered individually or as part of a High Grade Lymphoma FISH Panel (See the panel test for details).

Place a 5mm³ sample of involved tissue (solid tumor or other) in a sterile cup with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline.

Sterile cup with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline.

Fix the tissue in 10% formalin and prepare a Formalin-fixed, paraffin embedded (FFPE) tissue block

Either the entire block,  or two (2) 5 micron cuts mounted on positively charged slides and one H&E stained slide can be submitted for testing

FFPE tissue block or

Tissue section mounted on a charged, unstained slide

• AHL Cytogenetics oncology requisition

Ambient

• Improper label (unlabeled or mislabeled)
• Wrong container (anticoagulant or solution)
• Improper storage
• Leaking container
• Slides broken beyond repair

Fluorescence in situ hybridization (FISH)

Normal or Abnormal with interpretation

Medical necessity