Porphobilinogen, quantitative, 24-hour urine-994

Test info

  
Porphobilinogen, quantitative, 24-hour urine
  
994
  
LAB994
  
MSO
  
PBG, quantitative, 24-hour urine
Quantitative porphobilinogen, 24-hour urine
  

Porphobilinogen levels in the urine should be measured during acute attacks of abdominal pain, extremity pain or paresthesias, tachycardia, nausea and vomiting, neurologic abnormalities, and to investigate dark urine.

It is an initial test for acute intermittent porphyria, which is characterized by urinary excretion of porphobilinogen and δ-aminolevulinic acid during acute attacks. Increased urinary excretion of porphobilinogen may be caused also by acute attacks of variegate porphyria or of hereditary coproporphyria, and also in lead poisoning (rarely). In lead poisoning, urinary δ-aminolevulinic acid measurement is more useful.

Specimen

  
Urine, 24-hour
  
3.0 mL aliquot from a 24-hour collection
  
1.0 mL aliquot from a 24-hour collection
  

How to collect a 24 hr urine sample

Specimen must be kept refrigerated during collection

  
  1. Measure and record the 24-hour total volume
  2. Mix well
  3. Transfer the urine aliquot into a Amber screw-cap polypropylene frozen transport tube/vial - 4mL (LabCorp)
  4. Label with the patient's name, date, and time collection started and finished
  5. The specimen should be frozen immediately and maintained frozen until tested

Protect from light

  
  • Total volume
  

Frozen (preferred) - 1 month

Refrigerated - 24 hours

  
  • Specimen not refrigerated during collection
  • Specimen not protected from light
  • Specimen not a 24-hour collection
  • Specimen not frozen

Performance

  
LabCorp Burlington (003103): R-NX
  
Mo, We, Fr
  
3 - 5 days
  

Ion-exchange chromatography/spectrophotometry

Clinical and Interpretive info

  

Porphobilinogen,Qn,U:   0.0 − 2.0  mg/L
Porphobilinogen, 24U:   0.0 − 1.5 mg/24 hr

Billing

  
84110
  
Result 27382-1

Tracking

  
06/03/2019
  
12/22/2023
  
12/22/2023