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PML/RARA quantitative PCR-994

Test info

Test name:

PML/RARA quantitative PCR

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

(15;17)(q22;q12)
Acute myeloid leukemia
Acute promyelocytic leukemia
AML
AMPL
APL minimum residual disease
PML
PML/RARA
PML/RARA qnt

Useful for:

Diagnosis of acute promyelocytic leukemia (APL)
Detection of residual or recurrent APL
Monitoring the level of PML/RARA (promyelocytic leukemia/retinoic acid receptor alpha) in APL patients

Specimen

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

4.0 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

Bone marrow

Alternate collection container:

Lavender (EDTA), 4mL

Alternate transport container:

Lavender (EDTA), 4mL

Required forms/information:

Mayo Hematopathology/Cytogenetics test request

Transport and stability:

Refrigerated (preferred) - 5 days

Ambient (OK) - 72 hrs

Specimen retention time:

RNA is stored 3 months

Reason for rejection:

PCR testing cannot be added on to a sample that has been opened and/or used for other testing. If the sample has already been used for testing, a new specimen will need to be collected.

Performance

Performing lab:

Mayo Clinic Laboratories (PMLR): R-NX

Days set up:

Mo - Fr

TAT:

4 - 8 days

Method:

Quantitative, Real-Time Polymerase Chain Reaction (RT-PCR)

Clinical and Interpretive info

Reference ranges:

See report

Billing

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81315

Tracking

Date created:

02/06/2006

Revised date:

01/04/2024

Review date:

01/04/2024