Carcinoembryonic antigen, monoclonal, by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test info

Carcinoembryonic antigen, monoclonal, by IHC
12376 - Technical only, 12379 - Technical & interpretation
CEA, monoclonal
  • All IHC stains will include a positive control tissue
  • 95% of adenocarcinomas of colon, lung, breast, pancreas, biliary tract are CEA positive
  • Renal cell, prostatic, hepatocellular, adrenocortical, and thyroid carcinomas as well as mesotheliomas are usually negative for CEA
    NOTE: When CEA is ordered, the monoclonal CEA will be automatically performed unless the polyclonal antibody is specifically requested. Polyclonal CEA also reacts with NCA (nonspecific cross reacting antigens) and BGP (biliary glycoproteins). It is the unique CEA/BGP expression that is useful in identifying hepatocellular carcinomas (see section on immunohistochemistry panels). Thus, if the hepatocellular carcinoma panel is requested, then both monoclonal and polyclonal CEA will be automatically performed.



Prepare a formalin-fixed, paraffin-embedded (FFPE) tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair


AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination

Clinical and Interpretive info


If requested, an interpretive report will be provided



  • CEA is a family of HMW glycoproteins
  • Expression of CEA by tumor is often proportional to degree of differentiation
  • CEA also labels PMNs

Staining pattern

  • Cytoplasmic and apical based staining


88342 - 1st stain
88341 - each additional stain