7q31 Deletion/Monosomy 7 by FISH-4280G (bone marrow) or 4280H (blood)

Test info

  
7q31 Deletion/Monosomy 7 by FISH
  
4280G (bone marrow) or 4280H (blood)
  
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
  
7Q-
  
AML
Acute Myeloid Leukemia
Deletion 7q31
MDS
Monosomy 7
Myelodysplastic syndrome
7q-
FISH
Fluorescence In Situ Hybridization
MPN
Myeloproliferative Neoplasm
  

Loss/deletions of 7q are associated with myelodysplastic syndromes (MDS), chronic myeloproliferative neoplasms, particularly idiopathic myelofibrosis (IMF) and acute myeloid leukemia (AML).  They are also frequent abnormalities in therapy-related MDS and AML, following previous exposure to alkylating agents. According to current NCCN AML guidelines, a -7 result is classified as a poor/adverse cytogenetic risk factor.  In MDS, a -7/ 7q- result is classified as a poor cytogenetic risk factor.  In MPN -7/7q- is classified as an unfavorable cytogenetic risk factor. 

This test can be ordered individually or as part of the AML or MDS FISH Panels. See these panel tests for more details

Specimen

  
Bone Marrow aspirate
  

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

  1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
  2. Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

  
5 mL
  
3 mL
  

Transfer aspirate from syringe to transport container. 

  

Submit entire specimen unspun.

  

Sterile vial/tube

  

or

Dk green Sodium heparin (Na hep), no gel

  
Bone Marrow Core
Whole blood
Touch Prep Slides
  

Bone Marrow Core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or 

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  
Bone Marrow core: 10 mm
Whole blood: 5 mL
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.

  

Submit entire specimen unspun.

  
  

AHL Cytogenetics Oncology Request

  

Ambient

  
Specimens retained until completion of all testing
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Delay in transport
  • Improper storage
  • Leaking container
  • Slides broken beyond repair

Performance

  
AHL - Cytogenetics: X
  
Mo - Fr
  
7 business days
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation.

 

Billing

  
88271 x 2
88275
88291
  
Yes
  

Tracking

  
03/23/2021
  
10/03/2022