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SF3B1 mutation analysis-994

Test info

Test name:

SF3B1 mutation analysis

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

SF3B1 gene sequencing

Specimen

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

5 mL

Minimum volume:

2 mL

Collection instructions:

Immediately following collection, mix by inverting 8 - 10 times to prevent clotting

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

EDTA bone marrow

Alternate transport container:

Lavender (EDTA), 4mL

Transport and stability:

Refrigerated - <72 hours

Ship same day if possible

Performance

Performing lab:

NeoGenomics

Days set up:

Varies

TAT:

10 days

Method:

RT-PCR and bi-directional sequencing of exons 14-17 of the SF3B1 gene

Clinical and Interpretive info

Reference ranges:

An interpretive report will be provided

Clinical information:

SF3B1 mutations occur in 10-15% of CLL patients and serve as independent predictors of shortened time to treatment and poorer overall survival in CLL. Mutations are also detected in approximately 28% of MDS and 19% of myelodysplastic/myeloproliferative neoplasms. In MDS/MPN, most mutations were found in refractory anemia with ring sideroblasts (the RARS subtype).

Billing

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection

CPT codes:

81479

Subject to medical necessity (Y/N):

Yes

LCD/NCD:

Medical necessity

Tracking

Date created:

07/15/2019

Revised date:

06/23/2023