1q gain and 1p loss are recurring abnormalities in plasma cell dyscrasia disorders including Plasma Cell Myeloma.
According to current mSMART 3.0 myeloma guidelines, a gain of 1q is classified as a high-risk cytogenetic risk category. According to current NCCN myeloma guidelines, gains/amplification of 1q21 as well as 1p deletion increases the risk of progression, and incidence of the amplification is higher in relapsed than in newly diagnosed patients.
This test can be ordered individually or as part of a Plasma Cell Dyscrasia FISH Panel. See the individual panel test for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun. Specimen will be CD138 enriched for plasma cell isolation.
Bone Marrow Core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
or
Whole blood:
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.
Submit entire specimen unspun
AHL Cytogenetics Oncology Request
Ambient
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation