CSF3R mutation analysis-994

Test info

  
CSF3R mutation analysis
  
994
  
LAB994
  
MSO
  
Colony stimulating factor 3 receptor
CSF3R
  
Bi-directional sequencing of exons 14 and 17 of the CSF3R gene which includes detection of the common mutation T618I (also known as T595I).
  

CSF3R mutations are newly-identified genetic markers detected in 59% of chronic neutrophilic leukemia (CNL) or atypical chronic myeloid leukemia (aCML) that are useful for diagnosis and classification of these disorders. Identification of specific mutations may suggest the class of kinase inhibitors to which the tumor will be sensitive. Mutations are also detected in 30-80% of leukemia in patients with severe congenital neutropenia (SCN).

Specimen

  
EDTA whole blood
  

Lavender (EDTA), 4mL

  
4 mL
  

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

  

Lavender (EDTA), 4mL

  
Bone marrow
  
2 mL
  
  1. Place 2 mL of bone marrow into a Lavender (EDTA), 4mL tube.
  2. Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting
  

Refrigerated (preferred)

Ambient -

Frozen -

  
  • Improper label (unlabeled or mislabeled)
  • Clotted specimen
  • Improper anticoagulant or ratio
  • Improper storage/transport temperature

Performance

  
Neogenomics: R- NX
  
Varies
  
12 days
  

Molecular

Clinical and Interpretive info

Billing

  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
81479
  
Yes
  

Medical necessity

Tracking

  
10/18/2021
  
06/22/2023
  
01/03/2024