Alpha-fetoprotein (AFP), AChE, amniotic fluid with reflex to fetal hemoglobin (Hb F)-14381

Test info

  
Alpha-fetoprotein (AFP), AChE, amniotic fluid with reflex to fetal hemoglobin (Hb F)
  
14381
  
LAB14381
  
AFPACHE
  
α-fetoprotein (AFP), AChE, amniotic fluid with reflex to fetal hemoglobin (Hb F)
AFP
Alpha-fetoprotein, AChE, Hb F, amniotic fluid
  
  • Measurement of amniotic fluid AFP
  • Detection of AChE
  • The reflex to fetal hemoglobin (Hb F) will be used, if necessary, to ascertain false elevations of amniotic fluid AFP due to contamination with fetal blood
  

Analysis of midtrimester amniotic fluid for detection of open neural tube and ventral wall defects

  

AChE false-positive and false-negative results are more frequent at gestational ages of less than 13 weeks.

Specimen

  
  • The patient should have undergone ultrasound studies to verify fetal viability, detect multiple gestation, confirm gestational age, localize placenta, and detect fetal and uterine pathology
  • Patient's gestational age must be at least 12 weeks for interpretation of α-fetoprotein
  • Optimal gestational age for detection of AChE is 14 - 18 weeks

 

  
Amniotic fluid
  

Sterile vial/container

Do not use urine containers or tubes with rubber stoppers as rubber is toxic to amniocytes

  
3 mL
  

Avoid contamination of amniotic fluid with maternal or fetal blood. As little as one drop of fetal blood can cause false-positive results during assay of amniotic fluid.

  

Sterile vial/container

  
  • Gestational age by ultrasound and/or last menstrual period (LMP)
  

Ambient (preferred) - 7days

Refrigerated - NO

Frozen - NO

Performance

  
LabCorp RTP (510305): R-NX
  
Mo - Fr
  
6 - 10 days
  

Chemiluminescent immunoassay

Acrylamide gel electrophoresis

Isoelectric focusing

Clinical and Interpretive info

  

AFP - An interpretive report will be provided

AChE - Negative

Billing

  
82013
82106

Tracking

  
04/23/2020
  
09/22/2020
  
09/22/2020