Anti-Hu, Ri, Yo antibody profile, serum-994

Test info

  
Anti-Hu, Ri, Yo antibody profile, serum
  
994
  
LAB994
  
MSO
  

Evaluation of patients with suspected paraneoplastic neurologic syndrome such as encephalomyelitis

Specimen

  
Serum
  
  
2.0 mL
  
1.0 mL
  
  1. Allow specimen to clot
  2. Spin
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) labelled as "serum"
  

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x 3

  
1 week
  
  • Gross hemolysis
  • Gross lipemia

Performance

  
LabCorp Burlington (505240): R-NX
  
We (or as needed)
  
5 days
  

Immunofluorescence (IFA)

Clinical and Interpretive info

  

Negative

  

Antibodies to Hu, Ri and Yo antigens are present in patients with paraneoplastic neurologic syndrome such as encephalomyelitis. Hu antibodies are frequently associated with small cell lung cancer and neuroblastoma. Hu antibodies are rarely associated with non-small cell lung cancer, prostate cancer or seminoma. the paraneoplastic syndrome associated with the presence of antibodies to Ri includes symptoms such as opsocionus, ataxia, nystagmus, dizziness and dysarthria. Antibodies to Yo are associated with cerebellar degeneration as well as with small lung cancer, gynecologic and breast cancer.

Billing

  
86255 x 3

Tracking

  
01/29/2021
  
01/29/2021