Angiotensin-converting enzyme-13344

Test info

  
Angiotensin-converting enzyme
  
13344
  
LAB13344
  
ACE
  
ACE, serum
  

High in sarcoidosis, more often when the disease is active. Of value in assessing the response of sarcoidosis to corticosteroid therapy.

Specimen

  

Stop administration of Captopril, Enalapril, or Lisinopril for 12 hours prior to sample collection (reduces ACE activity).

  
Serum
  
  
0.5 mL
  
0.2 mL
  

Immediatley following collection, mix sample by inverting 5 times

  
  1. Allow specimen to clot for a minimum of 30 minutes
  2. Spin
  

Gold serum separator (SST) tube

  
  
  1. Allow specimen to clot
  2. Spin
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) labelled as "serum"
  
  

Ambient (preferred) - 7 days

Refrigerated - 7 days

Frozen - 3 days

Freeze/thaw cycles - stable x3

  
  • Captopril, enalapril, or lisinopril administration
  • Hemolyzed specimen
  • Icteric specimen
  • Whole blood,
  • Cerebrospinal fluid (CSF)
  • EDTA plasma specimen received

Performance

  
LabCorp Burlington (010116): R-LC
  
Mo - Sa
  
5 days
  

Kinetic

Clinical and Interpretive info

  

0 - 2 years:   18 - 95 units/L
3 - 14 years: 22 - 108 units/L
≥ 15 years:   14 - 82 units/L

  

Changes in serum ACE correlate with clinical status and results of gallium scans (which reflect presence and activity of inflammatory granulomatous lesions). Falling ACE level is a favorable prognostic sign. Rising levels may reflect activity uncontrolled by therapy.

Billing

  
82164
  
Result 2742-5

Tracking

  
03/27/2019
  
03/18/2022
  
03/17/2022