Clorazepate, serum or plasma-994
Test info
Clorazepate, serum or plasma
994
LAB994
MSO
Tranxene SD
Tranxene T-Tab
Tranxene T-Tab
- Evaluate toxicity
- Monitor therapeutic levels
The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel.
Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
Specimen
Serum
1.0 mL
0.4 mL
Unless otherwise directed, specimen should be collected just prior to next dose
- Allow sample to clot
- Spin within two (2) hours of sample collection
- Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum
Heparin plasma
EDTA plasma
EDTA plasma
Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting
- Spin within two (2) hours of sample collection
- Transfer plasma to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as the appropriate plasma type
Refrigerated (preferred) - 14 days
Ambient - 1 day
Frozen - 14 days
- Gel-barrier tubes
Performance
LabCorp Burlington (007930): R-NX
Tu - Fr
5 days
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Clinical and Interpretive info
Therapeutic: 0.5 - 2.0 µg/mL (reported as Nordiazepam)
Potentially toxic: >5.0 µg/mL (reported as Nordiazepam)
The drug is used in the treatment of general anxiety disorder, the management of ethanol withdrawal, and as an adjunct anticonvulsant drug.
- Half-life of elimination: 40 to 50 hours.
- Time to peak serum: approximately one hour.
Billing
80299
Yes
Tracking
05/21/2019
02/20/2024
02/20/2024