Porphyrins, quantitative, random urine-13518

Test info

  
Porphyrins, quantitative, random urine
  
13518
  
LAB13518
  
PORPHUR
  
Coproporphyrin
Uroporphyrin
  
  • Coproporphyrin (CP) I
  • Coproporphyrin (CP) III
  • Heptacarboxylporphyrins (7-CP)
  • Hexacarboxylporphyrins (6-CP)
  • Pentacarboxylporphyrins (5-CP)
  • Uroporphyrins (UP) 
  

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as acute intermittent porphyria (AIP), requires urine porphobilinogen (PBG) testing.

For initial evaluation of porphyrias. Use Porphyrins, Quantitative, 24-hour urine [13486] to follow upabnormal random urine results.

Specimen

  
Urine, random
  
  
2.0 mL
  
1.5 mL
  
  1. Transfer 2mL of to a Amber screw-cap polypropylene frozen transport tube/vial - 4mL (LabCorp)
  2. Freeze
  

Protect from light

Frozen (preferred) - 14 days

Freeze/thaw cycles - stable x3

Refrigerated - 7 days

Ambient - NO

 

  
  • Stored specimen not refrigerated
  • Specimen exposed to light
  • Acid preservative
  • pH <3

Performance

  
LabCorp Burlington (120980): R-LC
  
Mo - Fr
  
3 - 5 days
  

High-pressure liquid chromatography (HPLC) with fluorometric detection

Clinical and Interpretive info

  

 

Coproporphyrin (CP) I:   0−15 μg/L
Coproporphyrin (CP) III:   0−49 μg/L
Heptacarboxylporphyrins (7-CP): 0−2 μg/L
Hexacarboxylporphyrins (6-CP): 0−1 μg/L
Pentacarboxylporphyrins (5-CP): 0−2 μg/L
Uroporphyrins (UP):    0−20 μg/L
  

Excess urinary porphyrin excretion, or porphyrinuria, results from inhibition of key enzymatic steps in such clinical conditions as genetic deficiencies in heme production enzymes, hepatitis, renal disease, and erythroid disease, as well as by heavy metal inhibition of heme enzyme synthesis. Both in experimental animals and in humans exposed to heavy metals, elevated levels of porphyrins have been found in urine.

Billing

  
84120
  
Result 11228-4

Tracking

  
04/11/2019
  
12/14/2019
  
03/31/2022