CBFB by FISH-4280G (bone marrow) or 4280H (blood)

Test info

  
CBFB by FISH
  
4280G (bone marrow) or 4280H (blood)
  
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
  
CBFB
  
Acute Myeloid Leukemia
AML
CBFB-MYH11
FISH
Fluorescence in situ hybridization
inv(16)
t(16;16)
  

CBFB or inv(16) or t(16;16) are recurring abnormalities in AML.  According to current NCCN AML guidelines, these abnormalities are classified as a favorable cytogenetic risk factor.

This test can be ordered individually or as part of the AML FISH Panel. See the panel test for more details.

Specimen

  
Bone marrow aspirate
  

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

  1. Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
  2. Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

  
5 mL
  
3 mL
  

Transfer aspirate from syringe to transport container.

  

Submit entire specimen unspun. 

  

Sterile vial/tube

  

or

Dk green Sodium heparin (Na hep), no gel

  
Bone Marrow core
Sodium heparinized whole blood
Touch Prep slides
  

Bone Marrow Core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or 

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow core: 10 mm
Whole blood: 5 mL
  

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.

  

Submit entire specimen unspun.

  
  

AHL Cytogenetics Oncology Request

  

Ambient

  
Specimens retained until completion of all testing
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Delay in transport
  • Improper storage
  • Leaking container
  • Slides broken beyond repair

Performance

  
AHL - Cytogenetics: X
  
Mo - Fr
  
5 business days
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation

 

Billing

  
88271 x 2
88275
88291
  
Yes
  

Tracking

  
03/23/2021
  
09/14/2022