CBFB by FISH-4280H (blood) or 4280G (bone marrow)

Test info

  
CBFB by FISH
  
4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
CBFB
  
Acute Myeloid Leukemia
AML
CBFB-MYH11
FISH
Fluorescence in situ hybridization
inv(16)
t(16;16)
  

Detecting CBFB or inv(16) or t(16;16), which are recurring abnormalities in AML.

This test can be ordered individually or as part of the AML FISH Panel. See the panel test for more details.

Specimen

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2.0 mL
  

Only one specimen tube is required to perform all ordered cytogenetics testing.

The more testing requested, the closer to the optimal volume requirements is required.

  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whole blood:

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

EDTA whole blood:

Lavender (EDTA), 4mL

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

  
  • AHL Cytogenetics oncology request
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container

Performance

  
AHL - Cytogenetics: X
  
2 - 3 times per week
  
Routine: 5 - 7 days
STAT: Available upon request
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation

CBFB or inv(16) or t(16;16) are classified as favorable cytogenetics prognostic indicators in AML.

Billing

  
88271 x 2
88275
  
Yes
  

Tracking

  
03/23/2021