C2 Complement, Functional, Serum-1334

Test info

  
C2 Complement, Functional, Serum
  
1334
  
86160.3
  
C2
  
C2 Functional
C2 Complement, Functional, S, NR
C2FXN
  

Investigation of a patient with a low (absent) hemolytic complement

Specimen

  

Fasting preferred but not required

  
Serum
  
  
1 mL
  
0.5 mL
  

Immediately after specimen collection, place the tube on wet ice.

  
  1. Allow sample to clot on wet ice
  2. Spin within two (2) hours of sample collection
  3. Transfer serum to a Screw cap transfer vial/tube (Mayo T465), labelled as serum
  4. Immediately freeze specimen
  
  

Frozen - 21 days

  
14 days
  

Gross lipemia

Performance

  
Mayo Clinic Laboratories (C2FXN); R-NX
  
Mo - Fr
  
2-4 days
  

Automated Liposome Lysis Assay

Clinical and Interpretive info

  

25-47 U/mL

  
  • Low levels of complement may be due to inherited deficiencies, acquired deficiencies, or due to complement consumption (eg, as a consequence of infectious or autoimmune processes).
  • Absent (or low) C2 levels in the presence of normal C3 and C4 values are consistent with a C2 deficiency.
  • Low C2 levels in the presence of low C3 and C4 values are consistent with a complement-consumptive process.
  • Low C2 and C4 values, in the presence of normal values for C3 is suggestive of C1 esterase inhibitor deficiency.
  
As with all complement assays, proper sample handling is of utmost importance to ensure that the complement system is not activated before clinical testing.

Billing

  
86161

Tracking

  
11/07/2023
  
11/07/2023