Aneuploidy of chromosomes 4 and 10, is a recurring abnormality in B-cell ALL and an indication of hyperdiploidy. According to current NCCN B-ALL guidelines, gain of chromosomes 4 and 10 are classified as a favorable cytogenetic risk factor.
This test can be ordered individually or as part of the B-ALL FISH Panel. See the panel test for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.
Submit entire specimen unspun
AHL Cytogenetics Oncology Request
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.