TP53 by FISH-4280G (bone marrow) or 4280H (blood)

Test info

  
TP53 by FISH
  
4280G (bone marrow) or 4280H (blood)
  
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
  
TP53
  
Myeloma
Myeloma FISH panel
Plasma Cell Myeloma
TP53 deletion
17p13.1 deletion
FISH
Fluorescence In Situ Hybridization
  

TP53 deletion is a recurring abnormality in AML, CLL, MDS, and plasma cell dyscrasia disorders including Plasma Cell Myeloma.

TP53 deletion is a poor cytogenetic risk factor across several disorders including AML, CLL, MDS and myeloma.

This test can be ordered individually or as part of a Plasma Cell Dyscrasia FISH Panel (See the individual panel test for more details).

Specimen

  
Bone Marrow aspirate: 5 mL (minimum 3 mL)
  

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  
5 mL
  
3 mL
  

Transfer aspirate from syringe to transport container. 

 

  

Submit entire specimen unspun.

  

Sterile vial/tube

  

or

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow core
Sodium heparin (Na hep) whole blood
Touch prep slides
  

Bone marrow core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

or

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow core: 10 mm
Whole blood 5 mL
  

Whole Blood:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.

  

Submit entire specimen

  

 

Bone marrow core: 

Sterile vial/tube or cup

  

Whole Blood:

Dk green Sodium heparin (Na hep), no gel

  

AHL Cytogenetics oncology request

  

Ambient

  
Specimens retained until completion of all testing
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Delay in transport
  • Improper storage
  • Leaking container
  • Slides broken beyond repair

Performance

  
AHL - Cytogenetics: X
  
Mo-Fr
  
14 business days
  

Fluorescence in situ hybridization (FISH)

Clinical and Interpretive info

  

Normal or Abnormal with interpretation

 

Billing

  
88271 x 2
88275
88291
  
Yes
  

Tracking

  
03/16/2021
  
08/29/2022
  
09/08/2022