Renal cell carcinoma marker by IHC-12376 - Technical only, 12379 - Technical & interpretation

Test info

Renal cell carcinoma marker by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Useful in identifying cells of renal epithelial origin
  • RCC is detectable in 93% of primary and 84% of metastatic renal cell carcinomas
  • RCC also may react with breast lobular and ductal epithelium, epididymal tubular epithelium and colloid of thyroid follicles



Submit formalin-fixed, paraffin embedded (FFPE) tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair


AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination

Clinical and Interpretive info


If requested, an interpretive report will be provided



  • Human proximal nephrogenic renal antigen (carbohydrate domain of a glycoprotein)
  • RCC binds to a glycoprotein expressed in renal proximal tubule epithelial cells

Staining pattern

  • Membrane and coarse globular cytoplasmic staining


  1. Avery AK et al: Use of antibodies to RCC and CD 10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 24(2); 204-210, 2000.
  2. Yoshida SO et al: Monoclonal antibody to a proximal nephrogenic renal antigen: immuno9histochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas. Cancer Research, 49; 1802-1809, 1989.
  3. Oosterwijk E, et al: Immunohistochemical analysis of monoclonal antibodies to renal antigens: application in the diagnosis of renal cell carcinoma, AJP, 123,2:301-309, 1986.
  4. Vessella RL et al: Monoclonal antibodies to human renal cell carcinoma: recognition of shared and restricted tissue antigens. Cancer Research, 45: 6131-6139, 1985.


88342 - 1st stain
88341 - each additional stain