Help to diagnose drug-induced lupus (DIL) and systemic lupus erythematosus (SLE).
Antibodies to both chromatin and histones have been found in patients with procainamide-induced lupus; however, patients with lupus induced by drugs such as quinidine, penicillamine, methyldopa, and acebutolol have antibodies to chromatin but not antihistone. Antichromatin antibodies are found in 50% to 90% of SLE patients and have been linked with proteinuria in SLE patients.
Immediatley following collection, mix sample by gently inverting 5 times
Gold serum separator (SST) tube
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x3
Multiplex flow immunoassay
0.0 - 0.9 AI